![]() (2) Bioidentical progesterone was not included, but is known to be associated with no additional risk relative to estrogen alone. Notes: (1) Nested case–control studies (2015, 2019) based on data from the QResearch and Clinical Practice Research Datalink (CPRD) databases. Odds ratio (95% CI Tooltip confidence interval)Įstradiol/norgestrel or estradiol/drospirenoneĬonjugated estrogens/medroxyprogesterone acetate Risk of venous thromboembolism (VTE) with hormone therapy and birth control (QResearch/CPRD) The absolute risk of venous thromboembolism with EE/CPA-containing birth control pills is about 1.2 to 9.9 per 10,000 women-years. The risk of venous thromboembolism with EE/CPA-containing birth control pills is similar to that with EE and gestodene-, desogestrel-, and drospirenone-containing birth control pills and about 50 to 80% higher than with EE and levonorgestrel-containing birth control pills. The incidence of depression with EE/CPA is the same as that with other birth control pills. ![]() Side effects of EE/CPA include dysmenorrhea (10.2%), breast tension or tenderness (6.5%), headache (5.2%), nervousness (4.4%), chloasma (4.2%), depressed mood (3.4%), decreased libido (3.1%), varicosities (2.9%), nausea (1.9%), edema (1.7%), and dizziness (1.1%). It is taken once daily for 21 days, followed by a 7-day free interval. Available forms ĮE/CPA comes in the form of oral tablets and contains 35 or 50 μg EE and 2 mg CPA per tablet. It is also approved and used to treat androgen-dependent conditions in women such as acne, seborrhea, hirsutism, female pattern hair loss, and hyperandrogenism due to polycystic ovary syndrome. Medical uses ĮE/CPA is used as a combined birth control pill to prevent ovulation and pregnancy in women. The medication is taken by mouth once daily for 21 days, followed by a 7-day free interval. It is also used to treat androgen-dependent conditions in women such as acne, seborrhea, excessive facial/body hair growth, scalp hair loss, and high androgen levels associated with ovaries with cysts. Ethinylestradiol/cyproterone acetate ( EE/CPA), also known as co-cyprindiol and sold under the brand names Diane and Diane-35 among others, is a combination of ethinylestradiol (EE), an estrogen, and cyproterone acetate (CPA), a progestin and antiandrogen, which is used as a birth control pill to prevent pregnancy in women.
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